Physiologically Based Pharmacokinetic Model of CYP2D6 Associated Interaction Between Venlafaxine and Strong Inhibitor Bupropion—The Influence of Age-Relevant Changes and Inhibitory Dose to Classify Therapeutical Success and Harm

Luecht, Ulrich Ruben; Scholz, Wolfgang, Geiben, Ann-Kathrin; Haen, Ekkehard and Hempel, Georg (2025)

In: Pharmaceutics, 17(2), 179-179. doi:10.3390/pharmaceutics17020179

Research article (journal) | Peer reviewed | Published

Anwendung stark wirksamer retardierter Opioide in der Pädiatrie : Fallstricke und Lösungen für Morphin und Hydromorphon

Zimbelmann F, Flaute S, Deipenbrock M, Ahlke E, Hempel G, Baumann-Köhler M (2024)

In: Der Schmerz, 204. doi:10.1007/s00482-023-00775-w

Research article (journal) | Peer reviewed | Published

Development and validation of a bioanalytical method for the quantification of methotrexate from serum and capillary blood using volumetric absorptive microsampling (VAMS) and on-line solid phase extraction (SPE) LC-MS.

Opitz P, Fobker M, Fabian J, Hempel G (2024)

In: Journal of Chromatographic Science, 1715, 464610. doi:10.1016/j.chroma.2023.464610

Research article (journal) | Peer reviewed | Published

Systematic Evaluation of Pharmacokinetic Models for Model-Informed Precision Dosing of Meropenem in Critically Ill Patients Undergoing Continuous Renal Replacement Therapy.

Schatz, LM; Brinkmann, A; Röhr, A; Frey, O; Greppmair, S; Weinelt, F; Zoller, M; Scharf, C; Hempel, G; Liebchen, U (2023)

In: Antimicrobial Agents and Chemotherapy, 1. doi:10.1128/aac.00104-23

Research article (journal) | Peer reviewed | Published

Developing a Method for Quantifying Meropenem in Children-Volumetric Adsorptive Microsampling Versus Plasma Sampling

Ramadan O, Schatz LM, van den Heuvel I, Masjosthusmann K, Groll AH, Hempel G (2023)

In: Therapeutic Drug Monitoring, 45(5), 623-630.

Research article (journal) | Peer reviewed | Published

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Development and Validation of a Quantification Method for Direct Oral Anticoagulants from Capillary Blood using volumetric absorptive microsampling and online SPE-LC-MS Patrick Opitz; Isabel Waltering; Georg Hempel (2025) In: Journal of Chromatography B, 1251, 124423. doi:10.1016/j.jchromb.2024.124423 Research article (journal) \| Peer reviewed \| Published
Physiologically Based Pharmacokinetic Model of CYP2D6 Associated Interaction Between Venlafaxine and Strong Inhibitor Bupropion—The Influence of Age-Relevant Changes and Inhibitory Dose to Classify Therapeutical Success and Harm Luecht, Ulrich Ruben; Scholz, Wolfgang, Geiben, Ann-Kathrin; Haen, Ekkehard and Hempel, Georg (2025) In: Pharmaceutics, 17(2), 179-179. doi:10.3390/pharmaceutics17020179 Research article (journal) \| Peer reviewed \| Published
Determination of Fluconazole in Children in Small Blood Volumes Using Volumetric Absorptive Microsampling (VAMS) and Isocratic High-Performance Liquid Chromatography–Ultraviolet (HPLC–UV) Detection Zimbelmann F, Groll AH, Hempel G. (2025) In: Pharmaceutics, 17(5), 592. doi:10.3390/pharmaceutics17050592 Research article (journal) \| Peer reviewed \| Published
Anwendung stark wirksamer retardierter Opioide in der Pädiatrie : Fallstricke und Lösungen für Morphin und Hydromorphon Zimbelmann F, Flaute S, Deipenbrock M, Ahlke E, Hempel G, Baumann-Köhler M (2024) In: Der Schmerz, 204. doi:10.1007/s00482-023-00775-w Research article (journal) \| Peer reviewed \| Published
Proof of concept of physiologically based pharmacokinetic modelling in paediatric acute lymphoblastic leukaemia Bauch T, Hempel G. (2024) In: British Journal of Haematology, 204(6), 2324-2331. doi:10.1111/bjh.19410 Research article (journal) \| Peer reviewed \| Published
Development and validation of a bioanalytical method for the quantification of methotrexate from serum and capillary blood using volumetric absorptive microsampling (VAMS) and on-line solid phase extraction (SPE) LC-MS. Opitz P, Fobker M, Fabian J, Hempel G (2024) In: Journal of Chromatographic Science, 1715, 464610. doi:10.1016/j.chroma.2023.464610 Research article (journal) \| Peer reviewed \| Published
Development and Validation of a High-Performance Liquid Chromatography With Ultraviolet Detection Method to Facilitate Therapeutic Monitoring of Teicoplanin Using Dried Blood Spots Ramadan, O.[1]; Opitz, P.[2,3]; Hempel, G. [4] (2024) In: Therapeutic Drug Monitoring, 00, 1-7. doi:10.1097/FTD.0000000000001202 Research article (journal) \| Peer reviewed \| Published
Systematic Evaluation of Pharmacokinetic Models for Model-Informed Precision Dosing of Meropenem in Critically Ill Patients Undergoing Continuous Renal Replacement Therapy. Schatz, LM; Brinkmann, A; Röhr, A; Frey, O; Greppmair, S; Weinelt, F; Zoller, M; Scharf, C; Hempel, G; Liebchen, U (2023) In: Antimicrobial Agents and Chemotherapy, 1. doi:10.1128/aac.00104-23 Research article (journal) \| Peer reviewed \| Published
Validation of a liquid chromatography-tandem mass spectrometry method for simultaneous quantification of N,N-dimethylacetamide and N-monomethylacetamide in pediatric plasma Rosser SPA, McLachlan AJ, Hempel G, Chung J, Shaw PJ, Keogh SJ, Nath CE (2023) In: Journal of Separation Science, 46(10). doi:10.1002/jssc.202201003 Research article (journal) \| Peer reviewed \| Published
Developing a Method for Quantifying Meropenem in Children-Volumetric Adsorptive Microsampling Versus Plasma Sampling Ramadan O, Schatz LM, van den Heuvel I, Masjosthusmann K, Groll AH, Hempel G (2023) In: Therapeutic Drug Monitoring, 45(5), 623-630. Research article (journal) \| Peer reviewed \| Published