PDCD4 controls the G1/S-phase transition in a telomerase-immortalized epithelial cell line and affects the expression level and translation of multiple mRNAs

Haas A, Nilges BS, Leidel SA, Klempnauer K-H (2020)

In: Scientific Reports, 2020.

Research article (journal) | Peer reviewed | Published

A novel cell-based screening assay for small-molecule MYB inhibitors identifies podophyllotoxins teniposide and etoposide as inhibitors of MYB activity.

Yusenko M, Jakobs A, Klempnauer KH (2018)

In: Scientific Reports, 8.

Research article (journal) | Peer reviewed | Published

Interplay with the Mre11-Rad50-Nbs1 complex and phosphorylation by GSK3β implicate human B-Myb in DNA-damage signaling

Henrich S., Usadel C., Werwein E., Burdova K., Janscak P., Ferrari S., Hess D., Klempnauer K. (2017)

In: Scientific Reports, 7(null). doi:10.1038/srep41663

Research article (journal) | Peer reviewed | Published

Withaferin A, a natural compound with anti-tumor activity, is a potent inhibitor of transcription factor C/EBPβ

Falkenberg K., Jakobs A., Matern J., Dörner W., Uttarkar S., Trentmann A., Steinmann S., Coulibaly A., Schomburg C., Mootz H., Schmidt T., Klempnauer K. (2017)

In: BBA - Molecular Cell Research, 1864(7), 1349-1358. doi:10.1016/j.bbamcr.2017.05.003

Research article (journal) | Peer reviewed | Published

Small-molecule disruption of the Myb/p300 cooperation targets acute myeloid leukemia cells

Uttarkar S., Piontek T., Dukare S., Schomburg C., Schlenke P., Berdel W., Muller-Tidow C., Schmidt T., Klempnauer K. (2016)

In: Molecular Cancer Therapeutics, 15(12), 2905-2915. doi:10.1158/1535-7163.MCT-16-0185

Research article (journal) | Peer reviewed | Published

Publications

Operated by

Top-Links

Natural Products with Antitumor Potential targeting the MYB-C/EBPbeta-p300 Transcription Module Schmidt TJ, Klempnauer K-H. (2022) In: Molecules, 27. doi:10.3390/molecules27072077 Research article (journal) \| Peer reviewed \| Published
PDCD4 controls the G1/S-phase transition in a telomerase-immortalized epithelial cell line and affects the expression level and translation of multiple mRNAs Haas A, Nilges BS, Leidel SA, Klempnauer K-H (2020) In: Scientific Reports, 2020. Research article (journal) \| Peer reviewed \| Published
Activation of the oncogenic transcription factor B-Myb via multisite phosphorylation and prolyl cis/trans isomerization. Werwein E, Cibis H, Hess D, Klempnauer KH (2019) In: Nucleic Acids Research, 47. Research article (journal) \| Peer reviewed \| Published
A novel cell-based screening assay for small-molecule MYB inhibitors identifies podophyllotoxins teniposide and etoposide as inhibitors of MYB activity. Yusenko M, Jakobs A, Klempnauer KH (2018) In: Scientific Reports, 8. Research article (journal) \| Peer reviewed \| Published
1. The natural anti-tumor compound Celastrol targets a Myb-C/EBPβ-p300 transcriptional module implicated in myeloid gene expression. Coulibaly A, Haas A, Steinmann S, Jakobs A, Schmidt TJ, Klempnauer KH. (2018) In: PloS one, 13. Research article (journal) \| Peer reviewed \| Published
Interplay with the Mre11-Rad50-Nbs1 complex and phosphorylation by GSK3β implicate human B-Myb in DNA-damage signaling Henrich S., Usadel C., Werwein E., Burdova K., Janscak P., Ferrari S., Hess D., Klempnauer K. (2017) In: Scientific Reports, 7(null). doi:10.1038/srep41663 Research article (journal) \| Peer reviewed \| Published
Targeting the transcription factor Myb by small-molecule inhibitors Uttarkar S., Frampton J., Klempnauer K. (2017) In: Experimental Hematology, 2017(47), 31-35. doi:10.1016/j.exphem.2016.12.003 Research article (journal) \| Peer reviewed \| Published
Withaferin A, a natural compound with anti-tumor activity, is a potent inhibitor of transcription factor C/EBPβ Falkenberg K., Jakobs A., Matern J., Dörner W., Uttarkar S., Trentmann A., Steinmann S., Coulibaly A., Schomburg C., Mootz H., Schmidt T., Klempnauer K. (2017) In: BBA - Molecular Cell Research, 1864(7), 1349-1358. doi:10.1016/j.bbamcr.2017.05.003 Research article (journal) \| Peer reviewed \| Published
Targeting acute myeloid leukemia with a small molecule inhibitor of the Myb/p300 interaction Uttarkar S., Dassé E., Coulibaly A., Steinmann S., Jakobs A., Schomburg C., Trentmann A., Jose J., Schlenke P., Berdel W., Schmidt T., Müller-Tidow C., Frampton J., Klempnauer K. (2016) In: Blood, 127(9), 1173-1182. doi:10.1182/blood-2015-09-668632 Research article (journal) \| Peer reviewed \| Published
Small-molecule disruption of the Myb/p300 cooperation targets acute myeloid leukemia cells Uttarkar S., Piontek T., Dukare S., Schomburg C., Schlenke P., Berdel W., Muller-Tidow C., Schmidt T., Klempnauer K. (2016) In: Molecular Cancer Therapeutics, 15(12), 2905-2915. doi:10.1158/1535-7163.MCT-16-0185 Research article (journal) \| Peer reviewed \| Published