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Publications

The potassium channel K2P2.1 shapes the morphology and function of brain endothelial cells via actin network remodeling. Lichtenberg S, Vinnenberg L, Steffen F, Plegge I, Hanuscheck N, Dobelmann V, Gruchot J, Schroeter CB, Ramachandran H, Wasser B, Bachir D, Nelke C, Franz J, Riethmüller C, Tenzer S, Distler U, Vogelaar CF, Kusche-Vihrog K, Skryabin BV, Rozhdestvensky TS, Schwab A, Krutmann J, Rossi A, Budde T, Bittner S, Meuth SG, Ruck T. (2025) In: Nature Communications, 16(1), 6622. doi:10.1038/s41467-025-61816-9 Research article (journal) \| Peer reviewed \| Published
MMF induces antioxidative and anaplerotic pathways and is neuroprotective in hyperexcitability in vitro Gola, L; Bierhansl, L; Hummel, N; Korn, L; Pawlowski, M; Cerina, M; Hundehege, P; Budde, T; König, S; Meuth, S; Wiendl, H; Kovac, S (2023) In: Free Radical Biology and Medicine, 194, 337-346. doi:10.1016/j.freeradbiomed.2022.12.010 Research article (journal) \| Peer reviewed \| Published
A novel NMDA receptor test model based on hiPSC-derived neural cells Disse P, Aymanns I, Ritter N, Peischard S, Korn L, Wiendl H, Pawlowski M, Kovac S, Meuth SG, Budde T, Strutz-Seebohm N, Wünsch B, Seebohm G (2023) In: Biological Chemistry, Ahead of Print. doi:10.1515/hsz-2022-0216 Research article (journal) \| Peer reviewed \| Published
Imaging of KCa3.1 Channels in Tumor Cells with PET and Small-Molecule Fluorescent Probes Thale, I.; Maskri, S.; Grey, L.; Todesca, L. M.; Budde, T.; Maisuls, I.; Strassert; C. A.; Koch, O.; Schwab, A.; Wünsch, B. (2023) In: ChemMedChem, 18(2), e202200551. doi:10.1002/cmdc.202200551 Research article (journal) \| Peer reviewed \| Published
Neuron-oligodendrocyte potassium shuttling at nodes of Ranvier protects against inflammatory demyelination. Kapell H; Fazio L; Dyckow J; Schwarz S; Cruz-Herranz A; Mayer C; Campos J; D Este E; Möbius W; Cordano C; Pröbstel AK; Gharagozloo M; Zulji A; Narayanan Naik V; Delank AK; Müntefering T; Cerina M; Sonner JK; Lerma-Martin C; Disse P; Sin JH; Sabeur K; Rychlik N; Srivastava R; Chavali M; Fitzgerald KC; Heidenreich M; Stadelmann C; Seebohm G; Platten M; Hemmer B; Budde T; Nave KA; Jentsch TJ; Engelhardt M; Green AJ; Acuna C; Calabresi PA; Friese MA; Schirmer L; Rowitch DH; Meuth SG (2023) In: Journal of Clinical Investigation, Ahead of Print. doi:10.1172/JCI164223 Research article (journal) \| Peer reviewed \| Published
Validation of TREK1 ion channel activators as an immunomodulatory and neuroprotective strategy in neuroinflammation. Schroeter CB; Nelke C; Schewe M; Spohler L; Herrmann AM; Müntefering T; Huntemann N; Kuzikov M; Gribbon P; Albrecht S; Bock S; Hundehege P; Neelsen LC; Baukrowitz T; Seebohm G; Bittner S; Wünsch B; Budde T; Ruck T; Meuth SG (2023) In: Biological Chemistry, Ahead of Print. doi:10.1515/hsz-2022-0266 Research article (journal) \| Peer reviewed \| Published
Characterization of Kv1.2-mediated outward current in TRIP8b-deficient mice Afsaneh Labbaf, Maurice Dellin, Marlene Komadowski, Dane M. Chetkovich, Niels Decher, Hans-Chrisitian Pape, Guiscard Seebohm, Thomas Budde, Mehrnoush Zobeiri (2023) In: Biological Chemistry, 404(4), 291-302. doi:10.1515/hsz-2023-0116 Research article (journal) \| Peer reviewed \| Published
Optimized synthesis and pharmacological evaluation of HCN channel inhibitor EC18 Marius Patberg; Tengiz Oniani; Paul Disse; Stefan Peischard; Laura Vinnenberg; Mehrnoush Zobeiri; Maria N. Romanelli; Lisa Epping; Heinz Wiendl; Sven G. Meuth; Petra Hundehege; Guiscard Seebohm; Thomas Budde; Anna Junker (2023) In: Archiv der Pharmazie / Chemistry in Life Sciences, e2200665. doi:10.1002/ardp.202200665 Research article (journal) \| Peer reviewed \| Published
Influence of inflammatory processes on thalamocortical activity Rychlik, Nicole; Hundehege, Petra; Budde, Thomas (2023) In: Biological Chemistry, 404(4), 303-310. doi:10.1515/hsz-2022-0215 Review article (journal) \| Peer reviewed \| Published
The second PI(3,5)P2 binding site in the S0 helix of KCNQ1 stabilizes PIP2-at the primary PI1 site with potential consequences on intermediate-to-open state transition. Dellin, Maurice; Rohrbeck, Ina; Asrani, Purva; Schreiber, Julian A; Ritter, Nadine; Glorius, Frank; Wünsch, Bernhard; Budde, Thomas; Temme, Louisa; Strünker, Timo; Stallmeyer, Birgit; Tüttelmann, Frank; Meuth, Sven G; Spehr, Marc; Matschke, Johann; Steinbicker, Andrea; Gatsogiannis, Christos; Stoll, Raphael; Strutz-Seebohm, Nathalie; Seebohm, Guiscard (2023) In: Journal of Biological Chemistry, 404(4), 241-254. doi:10.1515/hsz-2022-0247 Research article (journal) \| Peer reviewed \| Published