Broad rim lesions are a new pathological and imaging biomarker for rapid disease progression in multiple sclerosis

Klotz L*, Smolders J*, Lehto J, Matilainen M, Lütje L, Buchholz L, Albrecht S, Walter C, Varghese J, Wiendl H, Nylund M, Thomas C, Gardberg M, van den Bosch AMR, Airas L*, Huitinga I* & Kuhlmann T* (2025)

In: Nature Medicine, 31(6).

Forschungsartikel (Zeitschrift)

Broader anti-EBV TCR repertoire in multiple sclerosis: disease specificity and treatment modulation

Schneider-Hohendorf T, Wünsch C, Falk S, Raposo C, Rubelt F, Mirebrahim H, Asgharian H, Schlecht U, Mattox D, Zhou W, Dawin E, Pawlitzki M, Lauks S, Jarius S, Wildemann B, Havla J, Kümpfel T, Schrot MC, Ringelstein M, Kraemer M, Schwake C, Schmitter T, Ayzenberg I, Fischer K, Meuth SG, Aktas O, Hümmert MW, Kretschmer JR, Trebst C, Kleffner I, Massey J, Muraro PA, Chen-Harris H, Gross CC, Klotz L, Wiendl H, Schwab N. (2025)

In: Brain, 148(3).

Forschungsartikel (Zeitschrift)

Dietary habits in patients with relapsing-remitting multiple sclerosis and their correlation with clinical signatures of disease activity

Passlick, Johanna; Fleck, Ann-Katrin; Lauks, Sarah; Eveslage, Maria; Bergh, Florian Then; Kuempfel, Tania; Bittner, Stefan; Zipp, Frauke; Wiendl, Heinz; Klotz, Luisa (2024)

In: Multiple Sclerosis, 29.

Forschungsartikel (Zeitschrift)

Association of obesity with disease outcome in multiple sclerosis

Lutfullin I, Eveslage M, Bittner S, Antony G, Flaskamp M, Luessi F, Salmen A, Gisevius B, Klotz L, Korsukewitz C, Berthele A, Groppa S, Then Bergh F, Wildemann B, Bayas A, Tumani H, Meuth SG, Trebst C, Zettl UK, Paul F, Heesen C, Kuempfel T, Gold R, Hemmer B, Zipp F, Wiendl H, Lünemann JD, German Competence Network Multiple Sclerosis (KKNMS) (2023)

In: Journal of Neurology, Neurosurgery and Psychiatry, 94(1).

Forschungsartikel (Zeitschrift)

Dose-dependent expression of GFI1 alters metabolism in the haematopoietic progenitors and MLL::AF9-induced leukaemic cells

Patnana P.K.; Liu L.; Frank D.; Nimmagadda S.; Behrens M.; Ahmed H.; Xie X.; Liebmann M.; Wei L.; Gerdemann A.; Thivakaran A.; Humpf H.U.; Klotz L.; Dugas M.; Varghese J.; Trajkovic-Arsic M.; Siveke J.T.; Hanenberg H.; Opalka B.; Dührsen U.; Reinhardt H.C.; Guenther U.; von Bubnoff N.; Khandanpour C. (2023)

In: British Journal of Haematology, 202(5).

Forschungsartikel (Zeitschrift)

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Broad rim lesions are a new pathological and imaging biomarker for rapid disease progression in multiple sclerosis Klotz L, Smolders J, Lehto J, Matilainen M, Lütje L, Buchholz L, Albrecht S, Walter C, Varghese J, Wiendl H, Nylund M, Thomas C, Gardberg M, van den Bosch AMR, Airas L, Huitinga I & Kuhlmann T* (2025) In: Nature Medicine, 31(6). Forschungsartikel (Zeitschrift)
Suboptimal B-cell depletion is associated with progression independent of relapse activity in multiple sclerosis patients treated with ocrelizumab Revie L, Jürjens A, Eveslage M, Trümpelmann S, Teschner V, Schulte-Mecklenbeck A, Gross CC, Lünemann JD, Grosch J, Korsukewitz C, Wiendl H, Klotz L. (2025) In: Multiple Sclerosis, 31(7). Forschungsartikel (Zeitschrift)
Broader anti-EBV TCR repertoire in multiple sclerosis: disease specificity and treatment modulation Schneider-Hohendorf T, Wünsch C, Falk S, Raposo C, Rubelt F, Mirebrahim H, Asgharian H, Schlecht U, Mattox D, Zhou W, Dawin E, Pawlitzki M, Lauks S, Jarius S, Wildemann B, Havla J, Kümpfel T, Schrot MC, Ringelstein M, Kraemer M, Schwake C, Schmitter T, Ayzenberg I, Fischer K, Meuth SG, Aktas O, Hümmert MW, Kretschmer JR, Trebst C, Kleffner I, Massey J, Muraro PA, Chen-Harris H, Gross CC, Klotz L, Wiendl H, Schwab N. (2025) In: Brain, 148(3). Forschungsartikel (Zeitschrift)
Cell-mediated cytotoxicity within CSF and brain parenchyma in spinal muscular atrophy unaltered by nusinersen treatment Lu, I; Heming, M; Cheung, P; Thomas, C; Dag, M; Giglio, G; Schroeter, C; Nelke, C; Wirth, T; König, S; Siveke, J; Klotz, L; Leo, M; Wiendl, H; Hagenacker, T; Meyer zu Hörste, G (2024) In: Nature Communications, 15, 4120. Forschungsartikel (Zeitschrift)
Dietary habits in patients with relapsing-remitting multiple sclerosis and their correlation with clinical signatures of disease activity Passlick, Johanna; Fleck, Ann-Katrin; Lauks, Sarah; Eveslage, Maria; Bergh, Florian Then; Kuempfel, Tania; Bittner, Stefan; Zipp, Frauke; Wiendl, Heinz; Klotz, Luisa (2024) In: Multiple Sclerosis, 29. Forschungsartikel (Zeitschrift)
Chemokine-mediated cell migration into the central nervous system in progressive multifocal leukoencephalopathy Deffner M, Schneider-Hohendorf T, Schulte-Mecklenbeck A, Falk S, Lu IN, Ostkamp P, Müller-Miny L, Schumann EM, Goelz S, Cahir-McFarland E, Thakur KT, De Jager PL, Klotz L, Meyer Zu Hörste G, Gross CC, Wiendl H, Grauer OM, Schwab N. (2024) In: Cell reports. Medicine, 5 (7). Forschungsartikel (Zeitschrift)
Association of obesity with disease outcome in multiple sclerosis Lutfullin I, Eveslage M, Bittner S, Antony G, Flaskamp M, Luessi F, Salmen A, Gisevius B, Klotz L, Korsukewitz C, Berthele A, Groppa S, Then Bergh F, Wildemann B, Bayas A, Tumani H, Meuth SG, Trebst C, Zettl UK, Paul F, Heesen C, Kuempfel T, Gold R, Hemmer B, Zipp F, Wiendl H, Lünemann JD, German Competence Network Multiple Sclerosis (KKNMS) (2023) In: Journal of Neurology, Neurosurgery and Psychiatry, 94(1). Forschungsartikel (Zeitschrift)
Attenuation of immune activation in patients with multiple sclerosis on a wheat-reduced diet: a pilot crossover trial Engel, S.; Klotz, L.; Wirth, T.; Fleck, A.K.; Pickert, G.; Eschborn, M.; Kreuzburg, S.; Curella, V.; Bittner, S.; Zipp, F.; Schuppan, D.; Luessi, F. (2023) In: Therapeutic Advances in Neurological Disorders, 16. Forschungsartikel (Zeitschrift)
Dose-dependent expression of GFI1 alters metabolism in the haematopoietic progenitors and MLL::AF9-induced leukaemic cells Patnana P.K.; Liu L.; Frank D.; Nimmagadda S.; Behrens M.; Ahmed H.; Xie X.; Liebmann M.; Wei L.; Gerdemann A.; Thivakaran A.; Humpf H.U.; Klotz L.; Dugas M.; Varghese J.; Trajkovic-Arsic M.; Siveke J.T.; Hanenberg H.; Opalka B.; Dührsen U.; Reinhardt H.C.; Guenther U.; von Bubnoff N.; Khandanpour C. (2023) In: British Journal of Haematology, 202(5). Forschungsartikel (Zeitschrift)
Glycolytic interference blocks influenza A virus propagation by impairing viral polymerase-driven synthesis of genomic vRNA. Kleinehr J; Schöfbänker M; Daniel K; Günl F; Mohamed FF; Janowski J; Brunotte L; Boergeling Y; Liebmann M; Behrens M; Gerdemann A; Klotz L; Esselen M; Humpf HU; Ludwig S; Hrincius ER (2023) In: PLoS Pathogens, 19(7), e1010986. Forschungsartikel (Zeitschrift)