Impact of Antibodies Against Polyethylene Glycol on the Pharmacokinetics of PEGylated Asparaginase in Children with Acute Lymphoblastic Leukaemia: A Population Pharmacokinetic Approach

Siebel C, Lanvers-Kaminsky C, Alten J, Smisek P, Nath CE, Rizzari C, Boos J, Würthwein G (2021)

In: European Journal of Drug Metabolism and Pharmacokinetics, 2021. doi:10.1007/s13318-021-00741-w

Forschungsartikel (Zeitschrift) | Peer reviewed | Veröffentlicht

Asparaginase activities during intensified treatment with pegylated E. coli asparaginase in adults with newly-diagnosed acute lymphoblastic leukemia

Lanvers-Kaminsky C, Niemann A, Eveslage M, Beck J, Köhnke T, Martin S, Wit M, Spriewald B, Hauspurg H, Hoelzer D, Boos J, Gökbuget N (2020)

In: Leukemia & lymphoma, 61(1), 138-145. doi:10.1080/10428194.2019.1658099

Forschungsartikel (Zeitschrift) | Peer reviewed | Veröffentlicht

Therapeutic Drug Monitoring of Asparaginase: Intra-individual Variability and Predictivity in Children With Acute Lymphoblastic Leukemia Treated With PEG-Asparaginase in the AIEOP-BFM Acute Lymphoblastic Leukemia 2009 Study

Würthwein G, Lanvers-Kaminsky C, Gerss J, Möricke A, Zimmermann M, Stary J, Smisek P, Attarbaschi A, Nath C, Zucchetti M, Rizzari C, Schrappe M, Boos J (2020)

In: Therapeutic Drug Monitoring, 42(3), 435-444. doi:10.1097/FTD.0000000000000727

Forschungsartikel (Zeitschrift) | Peer reviewed | Veröffentlicht

Pre-existing antibodies against polyethylene glycol reduce asparaginase activities on first administration of pegylated E. coli asparaginase in children with acute lymphocytic leukemia

In: .

| Peer reviewed

Preclinical Evaluation of Combined Topoisomerase and Proteasome Inhibition Against Pediatric Malignancies

In: , -.

| Peer reviewed

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Impact of Antibodies Against Polyethylene Glycol on the Pharmacokinetics of PEGylated Asparaginase in Children with Acute Lymphoblastic Leukaemia: A Population Pharmacokinetic Approach Siebel C, Lanvers-Kaminsky C, Alten J, Smisek P, Nath CE, Rizzari C, Boos J, Würthwein G (2021) In: European Journal of Drug Metabolism and Pharmacokinetics, 2021. doi:10.1007/s13318-021-00741-w Forschungsartikel (Zeitschrift) \| Peer reviewed \| Veröffentlicht
Population Pharmacokinetics of PEGylated Asparaginase in Children with Acute Lymphoblastic Leukemia: Treatment Phase Dependency and Predictivity in Case of Missing Data Würthwein G, Lanvers-Kaminsky C, Siebel C, Gerß J, Möricke A, Zimmermann M, Stary J, Smisek P, Schrappe M, Rizzari C, Zucchetti M, Hempel G, Wicha SG, Boos J (2021) In: European Journal of Drug Metabolism and Pharmacokinetics, 46(2), 289-300. doi:10.1007/s13318-021-00670-8 Forschungsartikel (Zeitschrift) \| Peer reviewed \| Veröffentlicht
Asparaginase activities during intensified treatment with pegylated E. coli asparaginase in adults with newly-diagnosed acute lymphoblastic leukemia Lanvers-Kaminsky C, Niemann A, Eveslage M, Beck J, Köhnke T, Martin S, Wit M, Spriewald B, Hauspurg H, Hoelzer D, Boos J, Gökbuget N (2020) In: Leukemia & lymphoma, 61(1), 138-145. doi:10.1080/10428194.2019.1658099 Forschungsartikel (Zeitschrift) \| Peer reviewed \| Veröffentlicht
Can we optimise doxorubicin treatment regimens for children with cancer? Pharmacokinetic simulations and a Delphi consensus procedure Siebel C, Würthwein G, Lanvers-Kaminsky C, André N, Berthold F, Castelli I, Chastagner P, Doz F, English M, Escherich G, Frühwald MC, Graf N, Groll AH, Ruggiero A, Hempel G, Boos J (2020) In: BMC pharmacology & toxicology, 21(1). doi:10.1186/s40360-020-00417-2 Forschungsartikel (Zeitschrift) \| Peer reviewed \| Veröffentlicht
Therapeutic Drug Monitoring of Asparaginase: Intra-individual Variability and Predictivity in Children With Acute Lymphoblastic Leukemia Treated With PEG-Asparaginase in the AIEOP-BFM Acute Lymphoblastic Leukemia 2009 Study Würthwein G, Lanvers-Kaminsky C, Gerss J, Möricke A, Zimmermann M, Stary J, Smisek P, Attarbaschi A, Nath C, Zucchetti M, Rizzari C, Schrappe M, Boos J (2020) In: Therapeutic Drug Monitoring, 42(3), 435-444. doi:10.1097/FTD.0000000000000727 Forschungsartikel (Zeitschrift) \| Peer reviewed \| Veröffentlicht
Bioanalysis of doxorubicin aglycone metabolites in human plasma samples-implications for doxorubicin drug monitoring In: . \| Peer reviewed
Pre-existing antibodies against polyethylene glycol reduce asparaginase activities on first administration of pegylated E. coli asparaginase in children with acute lymphocytic leukemia In: . \| Peer reviewed
Asparagine levels in the cerebrospinal fluid of children with acute lymphoblastic leukemia treated with pegylated-asparaginase in the induction phase of the AIEOP-BFM ALL 2009 study In: , -. \| Peer reviewed
Preclinical Evaluation of Combined Topoisomerase and Proteasome Inhibition Against Pediatric Malignancies In: , -. \| Peer reviewed
Therapeutic Drug Monitoring of Asparaginase Activity-Method Comparison of MAAT and AHA Test Used in the International AIEOP-BFM ALL 2009 Trial In: , -. \| Peer reviewed