10-(4-Phenylpiperazine-1-carbonyl)acridin-9(10H)-ones and related compounds: Synthesis, antiproliferative activity and inhibition of tubulin polymerization

Waltemate J., Ivanov I., Ghasemi J. B., Aghaee E., Daniliuc C. G., Müller K., Prinz H. (2021)

In: Bioorganic and Medicinal Chemistry Letters, 32.

Forschungsartikel (Zeitschrift) | Peer reviewed | Veröffentlicht

Synthesis, antiproliferative activity evaluation and 3D-QSAR study of naphthoquinone derivatives as potential anti-colorectal cancer agents

Acuña, J Piermattey, J Caro, D Barrios, L Bannwitz, S López, J Ocampo, Y Vivas-Reyes, R Gaitán, R Aristizábal, F Müller, K Franco, L (2018)

In: Molecules, 23. doi:10.3390/molecules23010186

Forschungsartikel (Zeitschrift) | Peer reviewed | Veröffentlicht

Oxadiazole-substituted naphtho[2,3-b]thiophene-4,9-diones as potent inhibitors of keratinocyte hyperproliferation. Structure−activity relationships of the tricyclic quinone skeleton and the oxadiazole substituent

Basoglu A, Dirkmann S, Zahedi Golpayegani N, Vortherms S, Tentrop J, Nowottnik D, Prinz H, Fröhlich R, Müller K (2017)

In: European Journal of Medicinal Chemistry, 134, 119-132. doi:10.1016/j.ejmech.2017.03.084

Forschungsartikel (Zeitschrift) | Peer reviewed | Veröffentlicht

8-Halo-substituted naphtho[2,3-b]thiophene-4,9-diones as redox-active inhibitors of keratinocyte hyperproliferation with reduced membrane-damaging properties

Lindenschmidt C, Krane D, Vortherms S, Hilbig L, Prinz H, Müller K (2016)

In: European Journal of Medicinal Chemistry, 110, 280-290. doi:10.1016/j.ejmech.2016.01.040

Forschungsartikel (Zeitschrift) | Peer reviewed | Veröffentlicht

Synthesis and structure–activity relationships of lapacho analogues. 2. Modification of the basic naphtho[2,3-b]furan-4,9-dione, redox activation, and suppression of human keratinocyte hyperproliferation by 8-hydroxynaphtho[2,3-b]thiophene-4,9-diones

Bannwitz, V, Krane, D, Vortherms, S, Kalin, T, Lindenschmidt, C, Zahedi Golpayegani, N, Tentrop, J, Prinz, H, Müller, K (2014)

In: Journal of Medicinal Chemistry, 57(14), 6226-6239. doi:10.1021/jm500754d

Forschungsartikel (Zeitschrift) | Peer reviewed | Veröffentlicht

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10-(4-Phenylpiperazine-1-carbonyl)acridin-9(10H)-ones and related compounds: Synthesis, antiproliferative activity and inhibition of tubulin polymerization Waltemate J., Ivanov I., Ghasemi J. B., Aghaee E., Daniliuc C. G., Müller K., Prinz H. (2021) In: Bioorganic and Medicinal Chemistry Letters, 32. Forschungsartikel (Zeitschrift) \| Peer reviewed \| Veröffentlicht
A promising naphthoquinone [8-hydroxy-2-(2-thienylcarbonyl)naphtho[2,3-b]thiophene-4,9-dione] exerts anti-colorectal cancer activity through ferroptosis and inhibition of MAPK signaling pathway based on RNA sequencing Caro D, Rivera, D. E., Ocampo Y., Müller K., Franco, L. A. (2020) In: Open Chemistry, 18, 1242-1255. Forschungsartikel (Zeitschrift) \| Peer reviewed \| Veröffentlicht
Synthesis, antiproliferative activity evaluation and 3D-QSAR study of naphthoquinone derivatives as potential anti-colorectal cancer agents Acuña, J Piermattey, J Caro, D Barrios, L Bannwitz, S López, J Ocampo, Y Vivas-Reyes, R Gaitán, R Aristizábal, F Müller, K Franco, L (2018) In: Molecules, 23. doi:10.3390/molecules23010186 Forschungsartikel (Zeitschrift) \| Peer reviewed \| Veröffentlicht
Napabucasin and Related Heterocycle-Fused Naphthoquinones as STAT3 Inhibitors with Antiproliferative Activity against Cancer Cells Löcken H, Clamor C, Müller K (2018) In: Journal of Natural Products, 81(7), 1636-1644. doi:10.1021/acs.jnatprod.8b00247 Forschungsartikel (Zeitschrift) \| Peer reviewed \| Veröffentlicht
Oxadiazole-substituted naphtho[2,3-b]thiophene-4,9-diones as potent inhibitors of keratinocyte hyperproliferation. Structure−activity relationships of the tricyclic quinone skeleton and the oxadiazole substituent Basoglu A, Dirkmann S, Zahedi Golpayegani N, Vortherms S, Tentrop J, Nowottnik D, Prinz H, Fröhlich R, Müller K (2017) In: European Journal of Medicinal Chemistry, 134, 119-132. doi:10.1016/j.ejmech.2017.03.084 Forschungsartikel (Zeitschrift) \| Peer reviewed \| Veröffentlicht
N-Heterocyclic (4-phenylpiperazin-1-yl)methanones derived from phenoxazine and phenothiazine as highly potent inhibitors of tubulin polymerization Prinz H, Ridder A, Vogel K, Böhm KJ, Ivanov I, Ghasemi JB, Aghaee E, Müller K (2017) In: Journal of Medicinal Chemistry, 60(2), 749-766. doi:10.1021/acs.jmedchem.6b01591 Forschungsartikel (Zeitschrift) \| Peer reviewed \| Veröffentlicht
8-Halo-substituted naphtho[2,3-b]thiophene-4,9-diones as redox-active inhibitors of keratinocyte hyperproliferation with reduced membrane-damaging properties Lindenschmidt C, Krane D, Vortherms S, Hilbig L, Prinz H, Müller K (2016) In: European Journal of Medicinal Chemistry, 110, 280-290. doi:10.1016/j.ejmech.2016.01.040 Forschungsartikel (Zeitschrift) \| Peer reviewed \| Veröffentlicht
Inhibitory effect of phenothiazine- and phenoxazine-derived chloroacetamides on Leishmania major growth and Trypanosoma brucei trypanothione reductase Marcu A, Schurigt U, Müller K, Moll H, Krauth-Siegel RL, Prinz H (2016) In: European Journal of Medicinal Chemistry, 108, 436-443. doi:10.1016/j.ejmech.2015.11.023 Forschungsartikel (Zeitschrift) \| Peer reviewed \| Veröffentlicht
Synthesis and structure–activity relationships of lapacho analogues. 2. Modification of the basic naphtho[2,3-b]furan-4,9-dione, redox activation, and suppression of human keratinocyte hyperproliferation by 8-hydroxynaphtho[2,3-b]thiophene-4,9-diones Bannwitz, V, Krane, D, Vortherms, S, Kalin, T, Lindenschmidt, C, Zahedi Golpayegani, N, Tentrop, J, Prinz, H, Müller, K (2014) In: Journal of Medicinal Chemistry, 57(14), 6226-6239. doi:10.1021/jm500754d Forschungsartikel (Zeitschrift) \| Peer reviewed \| Veröffentlicht
Natural product derived antiprotozoal agents: Synthesis, biological evaluation, and structure-activity relationships of novel chromene and chromane derivatives Harel D., Schepmann D., Prinz H., Brun R., Schmidt T.J., Wunsch B. (2013) In: Journal of Medicinal Chemistry, 56(18), 7442-7448. doi:10.1021/jm401007p Forschungsartikel (Zeitschrift) \| Peer reviewed \| Veröffentlicht